
High-Normal Plasma Potassium Levels Lowers Risk of Ventricular Arrhythmias
By John Joseph Pack MD
Published on 05/10/2026
A strategy utilizing plasma K+ levels in the high-normal range, between 4.5 and 5.0 mmol's per liter, has been shown to help prevent ventricular arrhythmias, decrease ICD firing, and decrease cardiovascular mortality. Potassium plays a crucial role in myocardial cell function and electrical stability. Medications such as spironolactone and ACE Inhibitors have been shown to decrease the risk of sudden death from cardiovascular causes, and both medications help elevate K+ levels. High-normal potassium levels have repeatedly been tied to cardiac rhythm stability with lower risk of ventricular arrhythmias, lower risk of ICD firing, and lower risk of death. This strategy, though proven, needs to be individualized based on a myriad of factors, of course, as always, and with regular close monitoring of K+ levels.
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